Comparison of VA-P6 mutation frequencies associated with passage under mAb selection with predicted binding affinity changes (ΔΔG) induced by observed mutations.

The percent frequency of each mutation (from Table 3) is shown in the yellow-colored rows. In each ΔΔG row (in orange) the distances (Ångstroms) between the closest atoms from the RBD mutation and mAb interface residues are provided in parentheses.