Characterization of dengue complex-reactive epitopes on dengue 3 virus envelope protein domain III.
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The residues are located in the ED3 domain of the envelope protein. These residues were determined to be critical for the definition of the DENV complex-specific epitope. Other residues (V305, E309, D382, K383) are involved but not critical, and are considered to be in the periphery of the epitope. PRNT50 values were determined for the epitope-specific mAb by inhibition of infectivity on monkey kidney Vero cells. The PRNT50 values are higher than those previously obtained for DENV-2.
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IEDB创建时间：
2009-01-01
