EnHERV

The human genome contains a wide variety of endogenous retrovirus-like sequences. Human endogenous retroviruses (HERVs) comprise up to 6–8% of the human genome. From a junk DNA aspect, they become more interesting in biomedical world because of their expression tend to be associated with several diseases, including cancer and autoimmune diseases.EnHERV is a database designed for not only searching HERV neighboring gene, this database also provides an enrichment analysis function that allows users to perform enrichment analysis between selected HERV characteristics and user-input gene lists, especially genes with the expression profile of a certain disease. EnHERV will facilitate exploratory studies of specific HERV characteristics that control gene expression patterns related to various disease conditions.人类基因组中存在大量类内源性逆转录病毒序列。人类内源性逆转录病毒（Human Endogenous Retroviruses，HERVs）约占人类基因组的6%至8%。从垃圾DNA的研究视角来看，这类序列在生物医学领域愈发受到关注，因为其表达往往与癌症、自身免疫性疾病等多种疾病相关。EnHERV是一款专门面向HERV研究的数据库，它不仅支持HERV邻近基因的检索功能，还提供富集分析工具，允许用户针对选定的HERV特征与自定义输入的基因列表（尤其是携带特定疾病表达谱的基因）开展富集分析。EnHERV将助力针对调控与多种疾病相关的基因表达模式的特定HERV特征的探索性研究。