Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Myeloid Cells Regulates Metabolic Dysfunction-Associated Steatohepatitis (MASH)

Astrocyte elevated gene-1/Metadherin (AEG-1/MTDH) plays an important role in regulating lipid metabolism and inflammation in hepatocytes, and promotes metabolic dysfunction-associated steatohepatitis (MASH). Myeloid cells, such as macrophages, play a key role in regulating inflammation. Here we investigated the role of AEG-1 in myeloid cells in regulating high fat/high sugar diet (HF/HSD)-induced MASH. Both male and female AEG-1?MAC mice were significantly protected from MASH development compared to AEG-1fl/fl mice. Overall design: Littermates of myeloid cell-specific AEG-1 knockout mice (AEG-1DMAC) and AEG-1 floxed mice (AEG-1fl/fl) were fed either control diet (CD) or HF/HSD for 20 weeks.