Restoring neuronal iron homeostasis revitalizes neurogenesis after spinal cord injury

Spinal cord injury (SCI) can lead to iron overloading and subsequent neuronal ferroptosis, which hinders the recovery of locomotor function. Herein, we report the regulation of cellular iron homeostasis after SCI via the chelation of excess iron ions and modulation of the iron transportation pathway using polyphenol-based hydrogels for the revitalization of intrinsic neurogenesis. RNA-seq was used to explore the effects of the polyphenol-based hydrogels (TPC) on spinal cords at 7 days post-injury.