Dataset for: Plasmalogen homeostasis: regulation of plasmalogen biosynthesis and its physiological consequence in mammals

Plasmalogens, mostly ethanolamine-containing alkenyl ether phospholipids, are a major sub-class of glycerophospholipids. Plasmalogen synthesis is initiated in peroxisomes and completed in endoplasmic reticulum. The absence of plasmalogens in several organs of peroxisome biogenesis-defective patients suggests that<i> de novo</i> synthesis of plasmalogens plays a pivotal role in the plasmalogen homeostasis in tissues. Plasmalogen synthesis is regulated by modulating the stability of fatty acyl-CoA reductase 1 on peroxisomal membrane, a rate-limiting enzyme in plasmalogen synthesis, by sensing plasmalogens in the inner leaflet of plasma membranes. Dysregulation of plasmalogen homeostasis impairs cholesterol biosynthesis by altering the stability of squalene monooxygenase, a key enzyme in the cholesterol biosynthesis, implying physiological consequences of plasmalogen homeostasis in cholesterol metabolism in cells and organs such as liver.