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Crystal Structure of SARS-CoV-2 Mpro S113C in complex with Pfizer Intravenous Inhibitor PF-00835231

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Protein Data Bank Japan2026-01-28 更新2026-05-09 收录
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Crystal Structure of SARS-CoV-2 Mpro S113C in complex with Pfizer Intravenous Inhibitor PF-00835231 Descriptor: 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide Authors: Zvornicanin, S.N, Shaqra, A.M, Schiffer, C.A. Deposit date: 2025-04-14 Release date: 2025-12-10 Last modified: 2026-01-28 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease. Sci Adv, 12, 2026
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2025-04-14
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