An <i>Arabidopsis</i> mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile

Plant metabolism is constantly changing and requires input signals for efficient regulation. The mitochondrial calcium uniporter (MCU) couples organellar and cytoplasmic calcium oscillations leading to oxidative metabolism regulation in a vast array of species. In <i>Arabidopsis thaliana</i>, genetic deletion of AtMICU leads to altered mitochondrial calcium handling and ultrastructure. Here we aimed to further assess the consequences upon genetic deletion of AtMICU. Our results confirm that AtMICU safeguards intracellular calcium transport associated with carbohydrate, amino acid, and phytol metabolism modifications. The implications of such alterations are discussed.植物新陈代谢始终处于动态变化之中，需接收输入信号以实现高效调控。线粒体钙单向转运蛋白（mitochondrial calcium uniporter，MCU）可偶联细胞器与细胞质的钙振荡事件，进而在诸多物种中介导氧化代谢的调控。在拟南芥（Arabidopsis thaliana）中，敲除AtMICU基因会改变线粒体的钙处理能力及其超微结构。本研究旨在进一步评估敲除AtMICU基因所带来的后续效应。研究结果证实，AtMICU可保障与碳水化合物、氨基酸及植醇代谢修饰相关的细胞内钙转运过程的稳态。本文还对上述改变的潜在意义进行了探讨。