MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

We delineate the immunobiology during MYC oncogene-driven lymphomagenesis by RNA sequencing analysis followed by CIBERSORT of bulk splenic samples from healthy and SRa-tTA/tet-O-MYC mice before and after MYC inactivation. The data set also delineates global changes in signaling molecules in healthy spleens (controls) and lymphomagenic spleens in MYC ON and MYC OFF states. Overall design: mRNA profiles of splenic single cell suspensions from healthy normal (FVB/N), SRa-tTA/tet-O-MYC (MYC ON), and SRa-tTA/tet-O-MYC (MYC OFF/ Doxycycline) mice, in triplicate were analyzed using Beijing Genomics Institute (BGI) Sequencing (BGISEQ-500).