GPBAR1/TGR5 is a G protein–coupled receptor of bile acids. TGR5 is known to regulate the BA homeostasis and energy metabolism. Recent studies highlight an important role of TGR5 in alleviating obesity
We report increased levels of the hydrophobic bile acid T-βMCA during intestinal cancer progression using the APCmin/+ mouse tumor model. Likewise, HFD induced a shift in BA composition towards T-βMCA
