Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-066
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Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-066 Descriptor: Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl)ethyl]phosphonic acid Authors: Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. Deposit date: 2016-05-10 Release date: 2017-03-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60, 2017
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2016-05-10
