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CCL17 promotes colitis-associated tumorigenesis dependent on the microbiota

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP398293
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• CCL17 expression is increased in colitis-associated colon tumors • Single-housed CCL17-deficient mice develop fewer tumors dependent on the microbiota • Reduced tumor numbers coincide with increased apoptosis during tumor initiation Overall design: Sorted cells from tumors from CCL17 ko mice cohoused with control mice or CCL17 ko mice separately housed after AOM DSS treatment
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2023-07-01
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