Supporting evidence for regulator-target predictions.

TF = Transcription Factor; N of Tg. = Number of Predicted Targets at a fdr significance level of 0.05; CoCites = Papers which co-cite both Regulator and a predicted target, from PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) using Bioconductor package org.Hs.eg.db version 2.9.0 [80] restricted to papers with less than 150 gene links, and also from manual search of PMC (http://www.ncbi.nlm.nih.gov/pmc/); Tg. Co-Cites = Number of papers that cite at least two of the predicted targets, with (in brackets) the maximum number of targets in any one paper, from PubMed using Bioconductor package org.Hs.eg.db version 2.9.0 [80] restricted to papers with less than 150 gene links; Enriched GO annotations and Pathways using ConsensusPathDB [81]–[83] (R = Reactome, W = WikiPathways, P = Pathway Interactions Database, K = Kegg), with q-values and (in brackets) the number of genes from list (composed of a regulator and its predicted targets) in the GO annotation or pathway and the total number of genes in the GO annotation or pathway.