Zirconium Hydrazinediido Complexes Derived from Cyclic Hydrazines and Their Role in the Catalytic Synthesis of 1,7-Annulated Indoles
收藏NIAID Data Ecosystem2026-03-07 收录
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Reaction of cyclic 1,1′-disubstituted hydrazines with the bis(dimethylamido)zirconium complex [Zr{(NXyl)2Npy} (NMe2)2] (1) in the presence of dmap yielded the hexacoordinate zirconium hydrazinediido complexes [Zr{(NXyl)2Npy}(NNC9H10)(dmap)2] (2) and [Zr{(NXyl)2Npy}(NNC12H8)(dmap)2] (3). Hydrazinediides are thought to be key intermediates in the zirconium-catalyzed reaction of cyclic 1,1′-disubstituted hydrazines and disubstituted alkynes to yield 1,7-annulated indoles. Their basic structural motif is found in 5-HT3 receptor antagonists such as Cilansetron.
创建时间：
2016-02-19
