Kinetic parameters describing the interaction of PfCRTDd2_F145I with CQ and PPQ.
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Shown are the parameters from the two best models explaining the data presented in Fig 6. Vmax, maximal velocity of drug transport; KS, dissociation constant for the PfCRT-substrate complex; β, partiality factor; α, KS interaction factor; SEM, standard error; CI, confidence interval. N, number of determinations per kinetic analysis; n, total number of oocytes. For the CQ (PPQ) kinetics: N = 31, n = 630; for the PPQ (CQ) kinetics: N = 41, n = 625.
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2023-06-07



