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Induction of target genes of AP2-Sp in AP2-O::Sp parasites

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE18910
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Sporozoite-specific genes were induced in parasites that express AP2-O whose AP2 domain was swapped with that of AP2-Sp. DNA construct encoding AP2 domain of AP2-Sp was introduced into P. bergei schizonts. It was integrated into the locus of the endogenious AP2-O gene, resulting in swap of the AP2-domain (AP2-O::Sp parasites). Gene expression was analyzed in ookinetes cultured for 20h.
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2012-03-21
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