RMSD-values in nm of receptor conformations and observed PMF minima.

The X-ray crystal structures used for the closed, half-closed and open states had pdb identifiers 1FTM/2P2A, 1MQG and 1FTO, respectively. A clear correspondence of the observed minima and the receptor conformational states is found. Furthermore, the closed and half-closed receptor states appear consistently more similar to each other than either is to the open state, in good agreement to expectations.