Crystal structure of HCoV OC43 3CLpro with ALG-097608 (inhibitor 1)

Crystal structure of HCoV OC43 3CLpro with ALG-097608 (inhibitor 1) Descriptor: (1R,2R,3S,6S,7S)-4-[(2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-10,10-difluoro-N-{(1E,2R)-1-imino-3-[(3R)-2-oxo-3,4-dihydro-2H-pyrrol-3-yl]propan-2-yl}-4-azatricyclo[5.2.1.0~2,6~]decane-3-carboxamide (non-preferred name), 3C-like proteinase Authors: Reddem, E.R, Forouhad, F, Shapiro, L, Stoycheva, A. Deposit date: 2025-06-25 Release date: 2026-02-11 Last modified: 2026-04-15 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Structural basis for pan-coronavirus inhibition of 3CL protease. Structure, 34, 2026