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Inhibition of pyrimidine biosynthesis targets protein translation in AML [RNA-seq_MN-2]

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE181662
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Investigation of the transcriptional profile and compared with the genome accessibility (using ATAC-seq) in MN cells. Mice bearing MN tumors were treated with AG636 for 2 days. Leukemic stem cells (cKit high; CD11b low) from bone marrow and spleen were isolated. RNA sequencing and ATAC-seq were performed. Gene expression profiles of Vehicle- or AG636-treated MN AML cells.
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2022-07-20
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