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资源简介：
This data incldues matched exome data of patients who received immunotherapy.EGA dataset EGAD00001005227
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创建时间：
2019-08-21
相关数据集
NOD2 and ITPA causal variants in the exome sequencing data.
The composite phastCons is weighted sum of vertebrate cons, mammal cons and primate cons (shown in parenthesis), with weight 1/2, 1/3 and 1/6, respectively.
Figshare2015-12-02 更新50
Exome sequencing and peptide results by donor type (n = 77).
Exome sequencing and peptide results by donor type (n = 77).
Figshare2017-12-02 更新40
Whole exome sequencing summary statistics.
Whole exome sequencing summary statistics.
NIAID Data Ecosystem30
Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes
High-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component, approximately half of which cannot be explained by known genes. To discover genes, we analyse germline exome sequenc
NIAID Data Ecosystem50
Targeted sequencing of IDH1 and IDH2 genes was performed using bone marrow specimens from matched diagnosis and relapsed AML patients with IDH baseline mutation before or after IDHmut inhibitor treatment. gDNA was extracted from the bone marrow clot sections using the QuickExtract FFPE DNA extraction kit (Epicenter Biotechnologies) following the manufacturer's instructions. The exon sequences of IDH1 and IDH2 genes were PCR amplified. The DNA fragments for each exon were purified with QIAquick spin columns (Qiagen), mixed at equal molarity, and fragmented using Covaris acoustic shearing following the manufacturer’s instructions. Sonicated DNA was processed for library generation using NEBNext Ultra II DNA Kits (New England Biolabs) following the manufacturer’s protocol. Libraries with different index sequences were quantified, pooled, and sequenced on an Illumina Nextseq500 system using the 75bp high output sequencing kit.. Targeted sequencing of IDH1 and IDH2 genes in AML samples
Acquired resistance to allosteric inhibition of cancer-associated IDH mutations has been described through mutations to restore the production of oncometabolite R-2HG, yet the complete repertoire of I
NIAID Data Ecosystem30
