ObjectiveThis study was aimed to profile hotspot exonuclease domain mutations (EDMs) of the DNA polymerase ϵ gene (POLE) in endometrial cancer (EC) and to investigate the effects of EDMs on tumor cell
Background The molecular characterization of endometrial cancer (EC) can facilitate identification of various tumor subtypes. Although EC patients with POLE mutations reproducibly demonstrate better p
The PI3K pathway is altered in >85% of endometrioid endometrial carcinomas (EECs), with PTEN, PIK3CA and/or PIK3R1 mutations commonly co-occurring. Yet, the therapeutic effects of single-agent PI3K pa
