Additional file 15 of Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

Additional file 15: Table S11. List of DepMap cancer cell lines in WRNWT/WRNLOF groups. A. DepMap_ID: DepMap cancer cell lines IDs. stripped_cell_line_name: cell line names provided by DepMap without special characters or spaces. disease: cancer type assigned by DepMap. disease_subtype: cancer subtype assigned by Depmap. MS_status: inferred microsatellite status by Ghandi et al. (2019). Group: WRN group assigned (Control refers to the WTWT group; pan-cancer). Total_mutations: total number of mutations detected (LOF and non-LOF). LOF_mutations: number of LOF SNVs and insertion deletions detected (see Methods). CN_status: copy number status. KMT2D_prob: lethality probability when KMT2D is knocked out in the cell line. B. DepMap cancer cell lines that were previously validated to be dependent or independent of WRN. DepMap_ID: DepMap cancer cell lines IDs. stripped_cell_line_name: Cell line names provided by DepMap without special characters or spaces. disease: cancer type assigned by DepMap. Author: first author of study. WRN_dependence: whether authors showed WRN dependence. TRUE indicates KO of WRN was lethal to cell lines and FALSE indicates that cells were viable when WRN was knocked out. C. KMT2D and MMR mutations detected by DepMap WGS/WES characterization in cell lines from B.