Immunogenicity of Recombinant Rabies Virus-Vectored Multivalent Vaccines Expressing FCV VP1 and FHV-1 gB/gD Genes
收藏科学数据银行2025-12-16 更新2026-04-23 收录
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资源简介：
To develop a safe and effective multivalent vaccine against feline calicivirus (FCV) and feline herpesvirus 1 (FHV-1), two recombinant rabies virus (RABV) vaccines expressing the FCV VP1 and FHV-1 gB/gD genes were constructed. The exogenous genes showed stable inheritance, and the recombinant viruses exhibited growth kinetics similar to the parental strain. After verifying the viral pathogenicity, the recombinant virus vaccines elicited neutralizing antibody responses against FCV, FHV-1, and RABV, and conferred effective protection.
提供机构：
Yinyi Liang; Nuan Chen; Xiaolong Li; Louisiana State University; Hongling He; Jiahao Wang; Lerong Xin; Yueze Wang; South China Agricultural University; Xiaofeng Guo; Songze Zhao; Wanxing Xie
创建时间：
2025-12-16
