PIAS1 SUMOylates NR2C1 (TR2)
收藏reactome.org2025-01-21 收录
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https://reactome.org/PathwayBrowser/#/R-HSA-4717521
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As inferred from mouse homologs, PIAS1 SUMOylates NR2C1 (TR2) with SUMO1 at lysine-250. UnSUMOylated NR2C1 is localized to PML bodies and activates expression of OCT4. SUMOylated NR2C1 delocalizes from PML bodies and acts as a repressor of transcription.
据小鼠同源物推断，PIAS1在赖氨酸-250位点上通过SUMO1对NR2C1（TR2）进行SUMO化修饰。去SUMO化修饰的NR2C1定位于PML小体并激活OCT4的表达。SUMO化修饰的NR2C1从PML小体中转移，并作为转录的抑制子发挥作用。
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