Aging somatic cells are characterized by specific chromosome aneuploidy, particularly involving chromosomes Y (ChrY) and 21 (Chr21), which are associated with Alzheimer’s Disease (AD) pathology. This
The overall goal of the project is to assess the mRNA alterations in tauopathy conditions that occur at the presymptomatic stage of neurodegeneration. The animal model selected for this study is a wel
Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been show
Defects of autophagy-lysosomal protein degradation are thought to contribute to the pathogenesis of several neurodegenerative diseases, and the accumulation of aggregation prone proteins such as MAPT/