FEATURE

FEATURE is a suite of automated tools that examine biological structures and produce useful representations of the key biophysical and biochemical features of these structures that are critical for understanding function. The utility of this system extends from medical/pharmaceutical applications (model-based drug design, comparing pharmacological activities) to industrial applications (understanding structural stability, protein engineering). <br/><br/>This project includes the following software/data packages: <br/> <ul> <li> <a href="https://simtk.org/frs?group_id=16#pack_1731">Calcium Model 2015 </a> : The FEATURE calcium model was trained on a total of 314 calcium sites and 2,735 non-sites from 312 protein structures taken from the RCSB Protein Data Bank (PDB) using FEATURE 3.1. The calcium model provides the FEATURE scores for given points in a crystal structure, where higher scores indicate a higher likelihood of being an actual calcium site. </li> <li> <a href="https://simtk.org/frs?group_id=16#pack_1934">Errata to PLOS Publication </a> : Errata to PLOS Publication (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091240) </li> <li> <a href="https://simtk.org/frs?group_id=16#pack_1286">FEATURE 1.9 with Calcium Model </a> : FEATURE 1.9.1 stable release archive; if you are new to FEATURE, download FEATURE 3.0 instead. </li> <li> <a href="https://simtk.org/frs?group_id=16#pack_1501">FEATURE 3.1 </a> : FEATURE 3.1 Stable Release </li> <li> <a href="https://simtk.org/frs?group_id=16#pack_866">FEATURE Models </a> : Contains the SeqFEATURE library of models consisting of 136 models derived from 53 PROSITE patterns, plus an aditional 4 earlier manually curated models.All models were developed by the Stanford FEATURE development team </li> </ul>

FEATURE是一套自动化工具集，旨在检视生物结构并生成这些结构的关键生物物理和生化特征的实用表征，这些特征对于理解其功能至关重要。该系统的实用性涵盖从医疗/制药应用（基于模型的药物设计、比较药理活性）到工业应用（理解结构稳定性、蛋白质工程）。该项目包含以下软件/数据包：

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<li><a href="https://simtk.org/frs?group_id=16#pack_1731">钙模型2015</a>：FEATURE钙模型基于从RCSB蛋白质数据银行（PDB）中选取的312个蛋白质结构中的314个钙位点和2,735个非位点，使用FEATURE 3.1进行训练。该钙模型提供了晶体结构中特定点的FEATURE评分，评分越高表示该点实际为钙位点的可能性越大。</li>
<li><a href="https://simtk.org/frs?group_id=16#pack_1934">PLOS出版物勘误</a>：对PLOS Publications（http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091240）的勘误。</li>
<li><a href="https://simtk.org/frs?group_id=16#pack_1286">FEATURE 1.9带钙模型</a>：FEATURE 1.9.1稳定发布存档；如果您是FEATURE的新用户，请下载FEATURE 3.0。</li>
<li><a href="https://simtk.org/frs?group_id=16#pack_1501">FEATURE 3.1</a>：FEATURE 3.1稳定发布版。</li>
<li><a href="https://simtk.org/frs?group_id=16#pack_866">FEATURE模型</a>：包含由Stanford FEATURE开发团队开发的SeqFEATURE模型库，该库由从53个PROSITE模式中派生的136个模型以及额外的4个早期手工编写的模型组成。</li>
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