Dataset of preprocessed NII- and DTI-derived metrics from patients with ME/CFS and health controls with sedentary lifestyles

We provided the dataset of preprocessed diffusion-based neuroinflammation imaging (NII) and diffusion tensor imaging (DTI) derived metrics [NII-derived hindered water ratio (NII-HR), NII-derived hindered fraction of restricted isotropic diffusion (NII-RF), NII-derived fibre fraction (NII-FF), NII-derived axial diffusivity (NII-AD), NII-derived radial diffusivity (NII-RD), NII-derived mean diffusivity (NII-MD), NII-derived fractional anisotropy (NII-FA), DTI-derived fractional anisotropy (DTI-FA), DTI-derived mean diffusivity (DTI-MD), DTI-derived axial diffusivity (DTI-AD), and DTI-derived radial diffusivity (DTI-RD)] from 67 patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and 67 healthy controls (HCs) with sedentary lifestyles. The dataset can be used to replicate the results of the manuscript titled “Evidence of white matter neuroinflammation in myalgic encephalomyelitis/chronic fatigue syndrome: a diffusion-based neuroinflammation imaging study”. This manuscript investigated white matter neuroinflammation in ME/CFS using NII and their correlation with clinical symptoms. Details of data collection and processing can be found in the manuscript. The demographic and symptom scores were provided in the spreadsheet. Elenven subject-level datasets were determined: 1. NII_HR.nii: preprocessed NII-derived hindered water ratio; 2. NII_RF.nii: preprocessed NII-derived hindered fraction of restricted isotropic diffusion; 3. NII_FF.nii: preprocessed NII-derived fibre fraction; 4. NII_AD.nii: preprocessed NII-derived axial diffusivity; 5. NII_RD.nii: preprocessed NII-derived radial diffusivity; 6. NII_MD.nii: preprocessed NII-derived mean diffusivity; 7. NII_FA.nii: preprocessed NII-derived fractional anisotropy; 8. DTI_AD.nii.gz: preprocessed DTI-derived axial diffusivity; 9. DTI_RD.nii.gz: preprocessed DTI-derived radial diffusivity; 10. DTI_FA.nii.gz: preprocessed DTI-derived fractional anisotropy; 11. DTI_MD.nii.gz: preprocessed DTI-derived mean diffusivity.