The use of simulation-based sensitivity analyses is fundamental for evaluating and comparing candidate designs of future clinical trials. In this context, sensitivity analyses are especially useful to
Adaptive two-stage design with treatment selection, also called seamless Phase II/III design, has been recognized to save sample size and time to enhance the development of effective treatments. These
We review sequential designs, including group sequential and two-stage designs, for testing or estimating a single binary parameter. We use this simple case to introduce ideas common to many sequentia
