Structure of PYCR1 complexed with the allosteric inhibitor 7-benzamido-4-hydroxynaphthalene-2-sulfonic acid in a remote site and NADH and (S)-(-)-2-Hydroxy-3,3-dimethylbutyric acid in the active site

Structure of PYCR1 complexed with the allosteric inhibitor 7-benzamido-4-hydroxynaphthalene-2-sulfonic acid in a remote site and NADH and (S)-(-)-2-Hydroxy-3,3-dimethylbutyric acid in the active site Descriptor: (2S)-2-hydroxy-3,3-dimethylbutanoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 7-benzamido-4-hydroxynaphthalene-2-sulfonic acid, ... Authors: Tanner, J.J, Meeks, K.R. Deposit date: 2025-06-07 Release date: 2026-02-04 Last modified: 2026-03-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1. Biochem.J., 483, 2026