Differences in PBMC mRNA profiles between control and type 2 diabetic mice

Studies on immunometabolism have indicated that metabolism and the immunological state are inherently interconnected . Recent research has highlighted the impacts of metabolic syndrome on innate and adaptive immune function, which are linked to overall negative effects on the progression of related diseases . Notably, aging of immune system can be potentiated by dysmetabolism, culminating in chronic inflammation and immune fitness loss . Several age-related immune changes such as progressive loss of naive T cells, an increase in memory cells, and increased percentages of cells with immunosenescence markers, were identified in patients with T2DM . Dysfunction of both innate and adaptive immune responses in T2DM manifests similarly to aging, including poor control of infection and reduced vaccination response, along with elevated inflammatory activity.Hence, we sought to investigate the mechanism of accelerated immunosenescence during T2DM. Overall design: To investigate the mechanisms involved in T2DM-induced immunosenescence, we isolated PBMCs from T2DM and age-matched control mice for RNA sequencing