Transcriptome analysis of MCF-7 cells under hormonal deprivation and resveratrol treatment. Homo sapiens

MCF-7 human breast cancer cells acquire estrogen independent cell proliferation ability, when they are grown in the medium deprived of estrogen for an extended period (long term estrogen deprivation; LTED). This represents a cellular model for hormonal therapy resistance. On the other hand, phytoestrogen resveratrol (RES) inhibits the growth of breast cancer cells. In this study, we analyzed transcriptome of MCF-7 cells under LTED and RES treatment.