The lipid metabolism enzyme DGAT1 mediates Treg control of type 2 immunity at barrier sites
收藏官方服务：
资源简介：
The lipid metabolism enzyme DGAT1 mediates Treg control of type 2 immunity at barrier sites
应用场景：
创建时间：
2023-01-01
相关数据集
Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Solitary Isolated Lymphoid Tissues via purinergic signaling.. Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Solitary Isolated Lymphoid Tissues via purinergic signaling.
Gene expression comparison across CD11b+ cells from Csf2-sufficient and deficient mice. Overall design: Steady state isolated CD11b+ cells from colon lamina propria or solitary isolated lymphoid tissu
NIAID Data Ecosystem70
Disturbed mitochondrial dynamics in CD8+ TIL reinforce epigenetic programming linked with T cell exhaustion
The metabolic challenges present in tumors attenuate the metabolic fitness and anti-tumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic
NIAID Data Ecosystem60
D- 2-hydroxyglutarate is an immunometabolite that accumulates in macrophages after TLR activation and inhibits inflammatory responses
Macrophages undergo extensive metabolic rewiring upon activation and this serves many roles beyond the production of energy and anabolic building blocks. So-called immunometabolites that accumulate up
NIAID Data Ecosystem30
Additional file 8: of Transcriptomic data from two primary cell models stimulating human monocytes suggest inhibition of oxidative phosphorylation and mitochondrial function by N. meningitidis which is partially up-regulated by IL-10
GSEA core enrichment - Oxphos - IL-10 immunodepleted vs low LPS plasma. (XLS 61 kb)
NIAID Data Ecosystem70
Pro-survival Lipid Sphingosine-1-Phosphate Metabolically Reprograms T cell to Limit its Anti-Tumor Activity
Sphingosine 1-phosphate (S1P), a pro-tumor survival bioactive lysophospholipid, generated by sphingosine kinase 1 (SphK1), regulates lymphocyte egress into circulation via transducing S1P receptor 1 (
NIAID Data Ecosystem50
