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Design and Synthesis of Potent BACE-1 Inhibitors with Cellular Activity: Structure-Activity Relationship of P1 Substituents

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Protein Data Bank Japan2024-11-20 更新2026-03-21 收录
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Design and Synthesis of Potent BACE-1 Inhibitors with Cellular Activity: Structure-Activity Relationship of P1 Substituents Descriptor: Beta-secretase 1, N-[(1S,2R)-3-{[1-(3-tert-butylphenyl)cyclohexyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide Authors: Pan, H. Deposit date: 2009-09-01 Release date: 2010-01-05 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents. Bioorg.Med.Chem.Lett., 19, 2009
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2009-09-01
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