Profiling postnatal folliculogenesis in ovaries with loss of oocyte SUMOylation

SUMOylation plays a critical role in regulating protein function. In the ovary, disrupting expression of the E2 SUMO conjugation enzyme in mouse oocytes beginning at the primordial follicle stage results in female sterility and loss of the ovarian reserve in early adulthood. To determine how folliculogenesis is disrupted, we used label-free mass spectrometry to profile day 14 control and Ube2i-Gdf9icre ovaries.