Bertram2002_Gprotein_SynapticSignal

This a model from the article:
Role for G protein Gbetagamma isoform specificity in synaptic signal processing:
a computational study.

Bertram R, Arnot MI, Zamponi GW. J Neurophysiol
2002 May;87(5):2612-23 11976397
,
Abstract:

Computational modeling is used to investigate the functional impact of G
protein-mediated presynaptic autoinhibition on synaptic filtering properties. It
is demonstrated that this form of autoinhibition, which is relieved by
depolarization, acts as a high-pass filter. This contrasts with vesicle
depletion, which acts as a low-pass filter. Model parameters are adjusted to
reproduce kinetic slowing data from different Gbetagamma dimeric isoforms, which
produce different degrees of slowing. With these sets of parameter values, we
demonstrate that the range of frequencies filtered out by the autoinhibition
varies greatly depending on the Gbetagamma isoform activated by the
autoreceptors. It is shown that G protein autoinhibition can enhance the spatial
contrast between a spatially distributed high-frequency signal and surrounding
low-frequency noise, providing an alternate mechanism to lateral inhibition. It
is also shown that autoinhibition can increase the fidelity of coincidence
detection by increasing the signal-to-noise ratio in the postsynaptic cell. The
filter cut, the input frequency below which signals are filtered, depends on
several biophysical parameters in addition to those related to Gbetagamma
binding and unbinding. By varying one such parameter, the rate at which
transmitter unbinds from autoreceptors, we show that the filter cut can be
adjusted up or down for several of the Gbetagamma isoforms. This allows for
great synapse-to-synapse variability in the distinction between signal and
noise.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Bertram R, Arnot MI, Zamponi GW. (2002) - version=1.0

The original CellML model was created by:
Catherine Lloyd

[e-mail]
The University of Auckland
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