Synthesis of Organophosphorus Compounds through Copper-Catalyzed Annulation Involving C–O and C–P Bond Formations

A novel copper­(II) trifluoromethanesulfonate-catalyzed,
high-efficiency,
and atom-economical synthesis of valuable organophosphorus compounds
via cascade annulation of propargylic alcohols with diphenylphosphine
oxide is described. This protocol, which has a good functional-group
compatibility and insensitivity to an ambient atmosphere, provides
a simple and direct pathway to the products, organophosphorus compounds,
in good yields under mild conditions. The method could be efficiently
scaled up to gram scale, thus highlighting a potential application
of this methodology.