Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits

These files contain the data described in Broadaway (2024), AJHG, PMID: 39173627. Marginal eQTL summary stats: Column label Description Entrez Entrez ID Variant Chromosome_position_NonEffectAllele_EffectAllele CHR Chromosome POS Position (hg19) NEA Non-effect allele EA Effect allele EAF Effect allele frequency Beta Effect size of association between variant and gene SE Standard error PVAL p-value of association between variant and gene N Sample size for variant Studies Studies with gene expressed. 1=Germany (145), 2=Schadt (555), 3=Merck (322), 4 = BLP (161) GeneSymbol Gene symbol: lookup biomaRt (version 2.50.3, Ensembl version 110) ENSG Ensembl ID for gene: lookup biomaRt (version 2.50.3, Ensembl version 110) Gene_Biotype Gene Biotype: lookup biomaRt (version 2.50.3, Ensembl version 110) Files for download: Description Marginal eQTL full summary statistics – all results by chromosome Filename Liver_eQTL_Meta_Marginal_20240530.tar.gz Size 1.9 GB Date 5/30/2024 Isolated eQTL summary stats (each signal isolated): Column label Description GeneSymbol Gene symbol: lookup biomaRt (version 2.50.3, Ensembl version 110) Entrez Entrez ID SignalLead Lead variant of isolated signal Variant Chromosome_position_NonEffectAllele_EffectAllele NEA Non-effect allele EA Effect allele EAF Effect allele frequency Beta Effect size of association between variant and gene SE Standard error PVAL p-value of association between variant and gene N Sample size for variant Studies Studies with gene expressed. 1=Germany (145), 2=Schadt (555), 3=Merck (322), 4 = BLP (161) ENSG Ensembl ID for gene: lookup biomaRt (version 2.50.3, Ensembl version 110) Gene_Biotype Gene Biotype: lookup biomaRt (version 2.50.3, Ensembl version 110) Files for download: Liver_eQTL_Meta_Isolated_20240530.tar.gz Description Isolated conditional summary statistics for signficant signals – all results by chromosome Filename Size 1.5 GB Date 5/30/2024