RNA-Seq of Aged Polg Mutator Mouse Brains

We have performed both proteomic and transcriptomic analyses of the brains of one-year old Polg mutator mice. As part of this analysis, we generated RNA-Seq data from RNA isolated from one cerebral hemisphere of these mice. mRNA levels and protein abundance levels were compared in this study. 11 samples of RNA isolated from mouse cerebral hemisphere. 7 Polg D257A/D257A, 1 Polg D257A/WT, and 3 Polg WT/WT. The samples were collected from one-year old male mice.我们对一岁龄Polg突变（Polg mutator）小鼠的脑组织开展了蛋白质组学与转录组学联合分析。作为本次分析的一部分，我们从这些小鼠的单侧大脑半球分离得到RNA，并以此生成了RNA测序（RNA-Seq）数据。本研究对信使RNA（mRNA）表达水平与蛋白质丰度水平进行了比较分析。本次共包含11份从小鼠大脑半球分离得到的RNA样本，其中7份为Polg D257A/D257A基因型样本、1份为Polg D257A/WT基因型样本，剩余3份为Polg WT/WT野生型样本。所有样本均采集自一岁龄雄性小鼠。