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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

ChEBI2016-07-21 更新2026-07-12 收录

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数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-84636 数据链接链接失效反馈

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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

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创建时间：

2016-07-21

衰老生物学

蛋白质稳态

Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been established as a hallmark of nematode aging. However, whether proteostasis collapse occurs in humans has remaine

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The Plasmodium falciparum exported J domain proteins fine-tune human and malarial Hsp70s: Pathological exploitation of proteostasis machinery

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This dataset represents the documentation and supporting information for the following published review article submitted to Frontiers in Molecular Biosciences: "The Plasmodium falciparum exported J d

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Gene Expression Profiling in Tibial Muscular Dystrophy Reveals Unfolded Protein Response and Altered Autophagy

疾病分子病理学

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Tibial muscular dystrophy (TMD) is a late onset, autosomal dominant distal myopathy that results from mutations in the two last domains of titin. The cascade of molecular events leading from the causa

Figshare2016-01-18 更新20

SQSTM1/p62-mediated autophagy compensates for loss of proteasome polyubiquitin recruiting capacity

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选择性自噬机制

Protein homeostasis in eukaryotic cells is regulated by 2 highly conserved degradative pathways, the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy. Recent studies revealed a coordinat

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Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy

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线粒体稳态调控

The ubiquitin-proteasome pathway (UPP) is central to proteostasis network (PN) functionality and proteome quality control. Yet, the functional implication of the UPP in tissue homeodynamics at the who

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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

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