Comparison of fold change in transcript level between ibrutinib and vehicle treated animals with previously established transcriptional signatures from Itk deficient mice (Blomberg et al. 2009).

23 genes upregulated and 20 genes downregulated in CD3+ T-cells from Itk deficient mice are listed. Mean transcript levels of each genes in ibrutinib or vehicle treated animals are shown together with the fold change in level. The fold increases (≥ 1.5 fold) are colored red and the fold reductions (≤ 0.7 fold) blue.