Design of Fast Redox-Controlled Self-Immolative Selenium-Based Cysteine Surrogates
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https://figshare.com/articles/dataset/Design_of_Fast_Redox-Controlled_Self-Immolative_Selenium-Based_Cysteine_Surrogates/29136385
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资源简介：
The self-immolation of N-selenoethyl
cysteine
derivatives into cysteine exhibits a strong Thorpe–Ingold effect.
Notably, the gem-dimethyl substitution α to the selenium atom
achieved rate accelerations up to 252-fold, enabling Cys unmasking
through C–N bond cleavage within minutes. These investigations
offer valuable insights into the mechanism of selenoethyl arm breakdown
and new redox-sensitive Cys surrogates.
创建时间：
2025-05-23
