Iron(II)-Catalyzed Intramolecular Olefin Aminofluorination
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https://figshare.com/articles/dataset/Iron_II_Catalyzed_Intramolecular_Olefin_Aminofluorination/2285614
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资源简介：
An iron(II)-catalyzed diastereoselective
olefin aminofluorination
is reported (dr up to >20:1). This new transformation applies a
functionalized
hydroxylamine and Et3N·3HF as the nitrogen and fluorine
source, which facilitates the efficient synthesis of β-fluoro
primary amines and amino acids from allylic alcohol derivatives. Preliminary
mechanistic studies reveal that an iron–nitrenoid is a possible
intermediate and that its reactivity and enantioselectivity can be
efficiently modulated by ligands.
创建时间：
2016-02-17
