A new Cu(II)-based metal-organic framework constructed from the terpyridine tetrazolate ligand: structural characterization and anticancer activity on nasopharyngeal carcinoma
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https://tandf.figshare.com/articles/A_new_Cu_II_-based_metal-organic_framework_constructed_from_the_terpyridine_tetrazolate_ligand_structural_characterization_and_anticancer_activity_on_nasopharyngeal_carcinoma/11821641
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In the current study, a new Cu(II)-based metal-organic framework (MOF) formulated as {[Cu<sub>3</sub>(L)<sub>6</sub>(H<sub>2</sub>O)]·(H<sub>2</sub>O)<sub>4</sub>}<sub>n</sub> (<b>1</b>) (L = 4-(tetrazol-5-yl)phenyl-4,2′:6′,4″-terpyridine), has been synthesized by a solvothermal method and structurally characterized via the single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction along with the thermogravimetric analysis. After the synthesis of the compound <b>1</b>, its inhibitory effect on the viability of CNE-1 nasopharyngeal cancer cells were detected. Firstly, the Cell Counting Kit-8 (CCK-8) was performed to determine the anti-cancer activity of compound <b>1</b> <i>in vitro</i>, as well as the half maximal inhibitory concentration (IC<sub>50</sub>) value of compound <b>1</b>. In addition to this, Annexin V-FITC/PI assay was conducted the apoptosis of CNE-1 cells after compound <b>1</b> treatment. The H2DCF-DA assay was carried out to measure the ROS accumulation in CNE-1 cells after compound <b>1</b> treatment.
提供机构：
Taylor & Francis
创建时间：
2020-02-07
