Indole Diterpenoid Synthetic Studies. Construction of the Heptacyclic Core of (−)-Nodulisporic Acid D

Construction of the heptacyclic core of (−)-nodulisporic acid D, a representative member of a recently discovered class of architecturally
complex, ectoparasiticidal indole alkaloids, has been achieved. The modular synthetic strategy comprises an expedient, stereocontrolled
synthesis of a tricyclic western hemisphere, in conjunction with union of an eastern hemisphere, exploiting the 2-substituted indole synthetic
protocol introduced and developed in our laboratory.