Sensitive biomarkers.

Potential “sensitive biomarkers” of morphological disruption (i.e. ovotestis) in juvenile male rainbow trout gonads exposed chronically to ethynylestradiol. These genes represent the most differentially expressed genes in term of fold change and p-value in fish displaying intersex gonads (i.e. the two contrasts CT1 and CT2, corresponding to fish exposed to 0.01 and 0.1 μg EE2/L against the control group, respectively). The “Graph symbol” column refers to the letters represented on volcano plots in Fig 3C and 3D.