Dimerization of LIMK1 by Hsp90

After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain.

在Thr 508位点的磷酸化作用后，LIMK蛋白发生同源二聚化。同源二聚体的形成受热休克蛋白90（Hsp90）与LIMK激酶域中一段短序列的结合所促进。LIMK蛋白在形成同源二聚体之后，进一步发生激酶域的跨磷酸化作用。