Calcium regulation in cardiac cells

Calcium is a common signaling molecule. Once it enters the cytoplasm, it exerts allosteric regulatory effects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular matrix to the cytoplasm alters membrane depolarization. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarization of the heart. Source: [[wikipedia:Calcium_signaling|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP536 CPTAC Assay Portal]

钙作为一种常见的信号分子，在细胞质内发挥别构调节作用，对众多酶类及蛋白质产生影响。钙离子在离子通道激活引发的信号传导过程中，可充当第二信使，亦或是在G蛋白偶联受体等间接信号传导途径中发挥作用。钙离子从细胞外基质向细胞质内的迁移，改变了细胞膜的极化状态，这在心脏的室缩平台期尤为明显。在此实例中，钙离子维持心脏的去极化状态。相关通路上的蛋白质，可通过[https://assays.cancer.gov/available_assays?wp_id=WP536 CPTAC检测平台]获取相应的靶向检测。来源：[wikipedia:Calcium_signaling|维基百科]