Synchronous activation of striatal cholinergic interneurons induces local serotonin release

Striatal cholinergic interneurons (CINs) activate nicotinic acetylcholine receptors on dopamine axons to extend the range of dopamine release. Here we show that synchronous activation of CINs induces and extends the range of local serotonin release via a similar mechanism. This process is exaggerated in the hypercholinergic striatum of a mouse model of OCD-like behavior, implicating CINs as critical regulators of serotonin levels in the healthy and pathological striatum.
, , # Data from: Synchronous activation of striatal cholinergic interneurons induces local serotonin release

https://doi.org/10.5061/dryad.2z34tmq18

**Data Records**

The dataset comprises four primary MATLAB data structures (*patch_s3*, *optogenetics*, *perfusion_s1c*, and *electrical_stimultation*), together with two Excel data files associated with Fig. 3 and Supplementary Fig. 4. All datasets follow a nested experimental design in which slices are nested within mice. In MATLAB files all fluorescence traces are sampled at 31 Hz, and a shared variable (*time*) provides a common time vector.

**patch_s3**\
The “*patch_s3.mat”*  dataset contains electrophysiological recordings from multiple mice and cells. Each row in the struct represents one slice recorded across multiple experimental conditions, including *c2o*, *cciv_on*, *cciv_off*, and *led*. The *c2o* condition reports the onset of 920 nm laser scanning following scan initiation. The *cciv_on* and *cciv_off* conditions correspond t..., ,