Additional file 7 of Exploring the ATN classification system using brain morphology

Additional file 7. Comparing progression sequences towards AD pathology using selected ROIs and CSF-total-Tau. ROI based comparison of evidence for a monotonic volume decline over 6 possible sequences across ATN groups from A-T-N- towards A+T+N+ (ACH, ANT, TAN, TNA, NAT, NTA) including also non-AD continuum groups. Braak stage volumes are aggregated Freesurfer ROI volumes. ACH VX%: Percentage of voxels with highest evidence for ACH sequence inside the ROI mask. Neurodegeneration (N) by CSF Total Tau.