Electrophysiology and anatomy data for: Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

Head-direction (HD) signals function as the brain’s internal compass. They are organized as an attractor and anchor to the environment via visual landmarks. Here, we examine how thalamic HD signals and visual information from the retrosplenial cortex combine in the presubiculum. We find that monosynaptic excitatory connections from the anterior thalamic nucleus and from retrosplenial cortex converge on single-layer 3 pyramidal neurons in the dorsal portion of the mouse presubiculum. Independent dual wavelength photostimulation of these inputs in slices leads to action potential generation preferentially for near-coincident inputs, indicating that layer 3 neurons can transmit a visually matched HD signal to the medial entorhinal cortex. Layer 4 neurons, which innervate the lateral mammillary nucleus, form a second step in the association of HD and landmark signals. They receive little direct input from thalamic and retrosplenial axons. We show that layer 4 cells are excited di-synaptical..., , # Electrophysiology and anatomy data for: Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

Dataset DOI: [10.5061/dryad.9ghx3ffxd](https://doi.org/10.5061/dryad.9ghx3ffxd)

## Description of the data and file structure

Here are available electrophysiology data for the following research article: \"Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex\" ([https://doi.org/10.7554/eLife.92443.2](https://doi.org/10.7554/eLife.92443.2))

Data are provided in their original format (.abf) and can be opened using AxoGraph or with code language (Matlab, Python, etc...), using adequate script.

Data are organized by figures and some figures use the same data set.

For each figure, a unique .csv file summarizes the analysis for this figure, with a sheet for each figure panel.

Each .zip file of this dataset contains the data associated with a specific figure...,